Characteristics and standard techniques of medicinal gelatin
Pharmaceutical gelatin is mainly used for drug sustained-release materials and biofilm materials such as plasma, hemostatic sponges, soft and hard capsules, raw materials for tablet sugar coating, capsule materials for microspheres and microcapsules. Spray drying and freeze-drying processes were used to prepare succinyl gelatin for injection, and the drug was made into a solid preparation to improve its stability and ease of transportation and storage, which made up for the shortcomings of peptide biological product infusion, such as unstable drug properties and inconvenient transportation and storage.
It is important to note that most commercially available gelatin collagen is extracted from connective tissue and hard aggregate tissue of pigs and cattle, which limits the use of gelatin. Pig products are not available for a significant portion of the world's population, such as Hebrews, Muslims, vegetarians, and gelatin products are not labelled as having animal origin, so the use of gelatin in these populations is restricted. In recent years, due to the worldwide spread of mad cow disease (BSE), gelatin derived from animals should no longer be used for purposes such as animal feed or veterinary medicine. In addition, due to the hydrophilicity of gelatin, the hydrophilic substances in the contents migrate to the gelatin rubber shell, and the gelatin will react chemically with aldehyde-containing compounds, which limits its wide use, especially in traditional Chinese medicine. Therefore, the synthesis of collagen-like by chemical synthesis and the production of recombinant collagen and gelatin by genetic engineering technology are used to produce recombinant collagen and gelatin through different expression systems.
It solves the shortcomings of traditional extraction methods, improves the characteristics of hydrophilicity and immune rejection, and endows it with new biomedical properties, which has become a research hotspot in recent years. At the same time, the application and research of gelatin derivatives and their compounds have also received more and more attention and research, and the 20% lidocaine gelatin fiber mesh not only has a better hemostatic effect than oxidized cellulose and gelatin sponge, but also has a slow-release and analgesic effect.
Medicinal gelatin is a fat-free and high-protein prepared by complex physical and chemical treatment of animal skin, bone and tendon, which is easy to be absorbed by the human body, and has the physical characteristics of high viscosity, high freezing power and easy freezing.
Medicinal gelatin should be dry, clean, uniform, no inclusions, the appearance of light yellow to yellow fine particles, should pass through the pore size of 4mm standard sieve, its solution has no uncomfortable odor, people are used to call medicinal gelatin for medical gelatin, or pharmaceutical gelatin.
As a standard technical project for medicinal gelatin, it should be roughly the same as the technical project setting of edible gelatin, but the specific standards should be more stringent than the requirements for edible gelatin, so as to reflect the integration with international standards. In the project setting, it is necessary to retain 14 items such as moisture, freezing strength, transparency, ash, sulfur dioxide, pH value, water insoluble matter, chromium, arsenic, heavy metals, total number of bacteria, coliform bacteria, salmonella and other 14 items in the edible gelatin standard, and delete the plasma point item. Among them, transparency is mostly expressed by transmittance in foreign countries, but in China, whether it is a gelatin production plant or a gelatin user, due to historical reasons and habitual factors, it still wants to retain the transparency project, which we believe should be adopted.
Our company specializes in the production of pharmaceutical gelatin, food-grade gelatin, industrial-grade gelatin and other products, gelatin is one of the most important natural biological polymer materials, has been widely used in food, medicine and chemical industries!
